IndraLab

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STAMBPL1 binds AXL. 5 / 5
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"DUBs employ diverse mechanisms and modes of interaction with their substrates to mediate the removal of mono‐ubiquitin or poly‐ubiquitin chains from the target protein. [ xref ] To ascertain the direct interaction between STAMBPL1 and AXL, Immunoprecipitation (IP) and in vitro pull‐down assays were performed."
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"Based on their interaction, we next identified the critical region within STAMBPL1 that binds to AXL."
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"Our results showed truncated mutant lacking USP8_dimer domain exhibited much lower binding affinity with AXL comparing with STAMBPL1‐WT, STAMBPL1‐ΔUJ_linker and STAMBPL1‐ΔJAB, indicating that STAMBPL1 interacts with AXL largely through USP8_dimer domain (Figure  xref )."
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"First, our data showed that the interaction between STAMBPL1 and AXL proteins in KIRC cells was not affected upon GAS6 stimulation (Figure  xref )."
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"Thus, STAMBPL1 binding to AXL will sterically block TRIM21 from recognizing the AXL and inhibit the subsequent ubiquitination of AXL."
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