IndraLab

Statements

USP18 leads to the dephosphorylation of MAP3K7. 3 / 3
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"Mechanistically, androgen-activated androgen receptor (AR) upregulated expression of USP18, which inhibited TAK1 phosphorylation and the subsequent activation of NF-κB in anti-tumor T cells."
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"Hepatic ubiquitin specific protease 4 (USP4), USP18, and dual-specificity phosphatases 14 (DUSP14) can suppress TAK1 phosphorylation, besides tumor necrosis factor receptor associated factor 3 (TRAF3) and tripartite motif 8 (TRIM8) promote its phosphorylation."
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"USP18 can improve insulin sensitivity by deubiquitinating TAK1 and inhibiting TAK1 phosphorylation to downregulate NF-κB signaling pathway and upregulate fat mass and obesity-related protein (FTO) (153, 154)."
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