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USP38 activates AKT. 4 / 4
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"USP38 facilitates lactate export through MCT1, activates the AKT/mTOR pathway, and mitigates PM2.5‐induced lung injury."
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"In conclusion, these findings demonstrated that USP38 mitigates PM2.5‐induced lung epithelial cell damage by activating the AKT/mTOR pathway via MCT1, reducing lactate accumulation and apoptosis.4 Discussion."
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"Interestingly, we observed that USP38 activated the AKT/mTOR pathway and counteracted the inhibitory effects of PM2.5 (Figure 7C)."
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"By stabilizing MCT1, USP38 facilitates lactate export, thereby preventing intracellular lactate accumulation and reducing apoptosis.3.7 USP38 Activated the AKT/mTOR Pathway to Inhibit PM2.5-Induced Apoptosis."
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