IndraLab

Statements

sparser
"Compared to the control, USP13 overexpression increased HIF-1α levels, while the enzymatically inactive mutant USP13-AE (C345A/M664/739 [ xref ]) failed to maintain them, indicating that USP13 stabilizes HIF-1α via its deubiquitinase activity."
41272808
sparser
"Notably, USP13-AE mutants exerted no significant effects on migratory, invasive, or wound healing capacities, demonstrating that USP13-mediated enhancement of cellular motility strictly requires its deubiquitinase activity (Fig.  xref I, S4C, S4D)."
41272808
sparser
"Given previous findings that USP13 stabilizes HIF-1α through its deubiquitinase activity, stable USP13-AE overexpressing cells exhibited comparable proliferation rates to control groups (Fig. S4A), suggesting that USP13 promotes CRC cell proliferation in a deubiquitinase activity-dependent manner."
41272808