IndraLab

"These genes included: (1) 2 complexins (CPLX1 and CPLX2) and 3 synaptotagmins (SYT1, SYT2, and SYT3), which together regulate calcium-dependent exocytosis xref , xref ; (2) one of the synapsins (SYN2) which are involved in vesicle tethering and controlling the number of vesicles available for release xref ; (3) synaptophysin (SYP) which binds synaptobrevin (VAMP1) and plays a role in the control of exocytosis xref ; (4) one of the RIM family members (RIMS3) which interacts with voltage-dependent Ca 2+ channels and regulates neurotransmitter vesicle anchoring xref ; and (5) NSF and NAPA(SNAP-α) which bind and then dissociate SNARE complexes for synaptic vesicle recycling xref ."