IndraLab

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"Third, some experiments have concluded through mass spectrometry and protein blotting that UCHL3 may interact with GNG12 (G protein subunit gamma 12, a special G protein-coupled receptor that can participate in cancer immunity ( xref )."

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"Furthermore, we demonstrated that overexpression of GNG12 could restore the tumor inhibition effect caused by UCHL3 knock down, and UCHL3-GNG12 axis promote colon cancer progression via the NF-κB signal pathway."