IndraLab

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IHC inhibits BAP1. 20 / 20
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"Both FISH for the p16 deletion and IHC loss of BAP1 could not be shown in either case and were therefore not helpful in making the final diagnosis."
36636687
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"The most commonly referred to markers in malignant mesothelioma are loss of BAP1 by IHC, and the deletion of p16 by FISH."
33014860
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"Long-term follow-up was not available for these series [5,11]; thus, the question remains as to whether these tumors are atypical Spitz tumors or sporadic BAP1 associated melanocytic lesions.In summar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25479927
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"Another issue is that most mesotheliomas of peritoneal origin do show a loss of BAP1 by IHC but do not show loss of p16 by FISH."
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"In several studies, the loss of BAP1 by IHC and the homozygous deletion of p16 by FISH is very specific for mesothelioma but still may lack sensitivity to a certain extent."
33014860
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"In a recent study, BAP1 loss by IHC has been demonstrated to predict superior overall survival following first-line platinum-pemetrexed combination."
39312698
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"Given that BAP1 loss by IHC is observed in 15% of sporadic ccRCC (11), the probability that all 3 tumors would be BAP1 negative by chance alone is 0.0034."
23709298
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"There was a significant association between BRAF mutation status and loss of BAP1 by IHC."
22367297
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"It is worth emphasizing that morphology alone is insufficient for a diagnosis of MIS, while demonstration of BAP1 loss by IHC or CDKN2A/p16 homozygous deletion by FISH are required [13,24]."
36552912
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"Similarly, it is worth emphasizing that morphology alone is insufficient for diagnosis of MIS, and demonstration of BAP1 loss by IHC or CDKN2A homozygous deletion by FISH is required for diagnosis [13,24]."
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"Of note, their study also included peritoneal mesothelioma while ours is limited to pleural disease, and there is of course potential for variability in study populations.Like Sheffield et al [31], he[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26376834
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"To our surprise, none of the sarcomatoid cases in our study demonstrated BAP1 loss; and perhaps more surprisingly, there were multiple sarcomatoid-predominant biphasic cases that did demonstrate loss [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BAP1 nuclear loss by IHC is very sensitive to detect BAP1 biallelic inactivation, because approximately all pathogenic BAP1 mutations are either mutations abolishing the expression of the BAP1 protein or truncating mutations causing deletion of the nuclear translocation signal, or impairing the BAP1 deubiquitylating activity, which is required for BAP1 protein nuclear translocation [25]."
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"10 Somatic BAP1 loss by IHC is observed in up to 60% of pleural mesothelioma."
35945149
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"In addition, similar results were observed using the Mayo registry (a cohort of ~1,400 patients with non-metastatic ccRCC), where loss of BAP1 by IHC was associated with a markedly reduced rate of RCC-specific survival (HR, 3.06; 95% CI, 2.28 - 4.10; p = 6·"
35932824
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"Furthermore, our results suggested that BAP1 might be functionally inactivated in 44% of ESCC by IHC analysis, because BAP1 has been reported to function within the nucleus and BAP1 was not expressed within the nucleus in 44% of ESCCs."
26081045
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"If there is a strong suspicion for MPM, ancillary studies such as homozygous deletion of CDKN2A/p16 by FISH or the loss of BAP1 by IHC stain can further point toward a diagnosis of MPM."
30402386
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"The detection of BAP1 loss by IHC has been recognised as highly specific for MM, although the sensitivity of BAP1 loss detection is relatively low, approximately 50% for epithelioid histology, and even lower for sarcomatoid histology (50)."
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"These findings are comparable, as loss of BAP1 by IHC has been shown to correlate well with biallelic inactivation of BAP1.9 Although BAP1 loss was seen in only a small proportion (5%) of melanomas ov[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24018818
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"Detection of BAP1 loss by IHC has been recognized as highly specific for MM, although the sensitivity of BAP1 loss is relatively low at approximately 50% in epithelioid type of MM and much lower in sa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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