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USP3 inhibits MYD88. 3 / 3
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"We intend to perform long‐term experiments to investigate the duration of innate immune tolerance involving USP3 in the future.Although we found that USP3 inhibits MyD88‐dependent NF‐κB signaling activation by removing the K63‐linked polyubiquitin chains on MyD88, it remains unclear why K63‐linked polyubiquitin chains are so crucial for MyD88‐dependent NF‐κB signaling activation."
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"To identify the molecular target of USP3, we co‐transfected USP3 with different signaling proteins in the NF‐κB pathway and found that USP3 mainly inhibited MyD88‐induced NF‐κB activation and slightly but significantly inhibited TRAF6‐induced NF‐κB activity only at a high USP3 concentration (Fig 3A)."
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reach
"USP3 inhibits NF-kappaB signaling by targeting MyD88."
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