IndraLab

Statements

Gallic acid inhibits KCNH2. 6 / 6
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"The inhibition of I Kr, I Ks, and HERG by GA would induce a prolongation of APD, which could contribute to its antiarrhythmic actions because prolongation of APD could prevent or terminate the reentrant excitation and prolong the refractory period."
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"The results confirmed that GA blocks HERG."
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"GA (1, 5, and 10muM) inhibited I K (I Kr, I Ks) and the HERG K + current in a concentration dependent manner."
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"GA not only blocks the HERG channel, I K (I Kr, I Ks), but also inhibits I Na, so the results reveal that it has significant potential for development as a novel antiarrhythmic agent, particularly targeting the genesis of arrhythmias."
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"These effects of GA on channel kinetics were consistent with affinity for the inactivated state, suggesting that GA blocks the HERG channel by affecting its inactivation but not its activation."
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"GA blocked the HERG currents and the tail current in a concentration dependent manner."
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