IndraLab

Statements



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"A study by Chen et al. reported that USP21 promoted cell proliferation and metastasis in bladder cancer via deubiquitinating EZH2 and stabilizing it."

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"Subsequently, transwell assay and wound healing assay confirmed that USP21 promoted BC cells metastasis."

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"In bladder cancer, USP21 is highly expressed and patients with high expression levels have poor survival, and USP21 can accelerate the proliferation and metastasis of bladder cancer cells via inhibiting EZH2 ubiquitination."

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"USP21 promotes cell proliferation and metastasis through suppressing EZH2 ubiquitination in bladder carcinoma."

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"Another study showed that USP21 expression is upregulated in bladder tumors and suggested that USP21 could promote cancer growth and metastasis by inhibiting the ubiquitylation of EZH2 in bladder cancer cell lines [XREF_BIBR]."

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"In short, our results indicate that decreased expression of USP25 inhibits human NSCLC cell metastasis in vivo."