IndraLab

Statements

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"Additionally, USP21 could promote colorectal cancer metastasis through its functioning as a Fra-1 deubiquitinase [16]."
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"Another study showed that USP21 expression is upregulated in bladder tumors and suggested that USP21 could promote cancer growth and metastasis by inhibiting the ubiquitylation of EZH2 in bladder cancer cell lines [XREF_BIBR]."
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"USP21 up-regulation could also enhance colorectal cancer metastasis through functioning as a Fra-1 deubiquitinase [16]."
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"In bladder cancer, USP21 is highly expressed and patients with high expression levels have poor survival, and USP21 can accelerate the proliferation and metastasis of bladder cancer cells via inhibiting EZH2 ubiquitination."
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"Subsequently, transwell assay and wound healing assay confirmed that USP21 promoted BC cells metastasis."
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"Silencing of USP25 was shown to inhibit invasion and metastasis of human non-small cell lung cancer [52]."
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"For instance, USP21 regulates the ubiquitination of Fra-1 to accelerate metastasis in CRC[13]."
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"In bladder cancer cells, increased expression of USP21 promoted cell proliferation, stimulated cell migration and invasion, enhanced tumor metastasis (45)."
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"A study by Chen et al. reported that USP21 promoted cell proliferation and metastasis in bladder cancer via deubiquitinating EZH2 and stabilizing it."
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"Second, USP25 can promote cell growth and tumor metastasis."
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"These results strongly supported the crucial role of G3BP1 in USP21-mediated ESCC proliferation and metastasis."
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"Inhibition of USP25 by miRNA-200c in NSCLC cells significantly inhibited cell migration and metastasis (Li et al. 2014)."
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"USP21 promotes cell proliferation and metastasis through suppressing EZH2 ubiquitination in bladder carcinoma."
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"Yun et al. reported that USP21 promoted the liver metastasis of colorectal cancer cells via deubiquitinating and stabilizing Fra-1 [17]."
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"In short, our results indicate that decreased expression of USP25 inhibits human NSCLC cell metastasis in vivo."
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"In addition, USP9X can regulate EMT, while USP37 can stabilize c-MYC by the deubiquitination of USP21 and YY1, aiming to promote the metastasis of lung cancer cells (Pan et al., 2015; Cai et al., 2019; Xu et al., 2020)."
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"Here, in vitro and in vivo experiments revealed that aberrant upregulation of USP21 accelerated the proliferation and metastasis of ESCC in a deubiquitinase-dependent manner."
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