IndraLab

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USP22 activates SPI1. 6 / 6
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"On the other hand, USP22 deficiency decreases PU.1 stability to promote myeloid leukemia [10]."
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"Research has shown that USP22 can enhance myeloid differentiation in Kras mice by stabilizing the PU.1 protein and decreasing the risk of AML [14]."
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"Further, following CHX treatment, USP22 overexpression significantly attenuated SPI1 degradation, which in contrast, was strikingly facilitated in USP22 knockdown cells (Fig. 4i, j and Supplementary Fig. 4h, i)."
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"These results indicate that USP22 interacts with SPI1 and enhances SPI1 stability through deubiquitination."
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"Mechanistically, PRDM1 enhances USP22 transcription, thus reducing SPI1 protein degradation through deubiquitination, which enhances PD-L1 transcription."
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"Here, by utilizing the DUB siRNA library, we found that USP22 could reduce SPI1 protein degradation through deubiquitination."
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