IndraLab

Statements


Modified mutated MEF2 increases the amount of HCN4. 2 / 2
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"Overexpression of a dominant negative MEF2 mutant inhibits enhancer activity, decreases HCN4 mRNA expression and decreases If current amplitude, suggesting MEF2 may play a critical role in HCN4 transcription."

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"Furthermore, overexpression of a dominant negative MEF2 mutant inhibited the enhancer activity of CNS13, decreased Hcn4 mRNA expression and also decreased the amplitude of I (h) current in myocytes isolated from the inflow tract of embryonic heart."