IndraLab

Statements

Tax inhibits TNFAIP3. 5 / 5
| 5
sparser
"The inhibition of A20 by Tax may contribute to the constitutive activation of NF-κB in HTLV-1 infected cells."
21135871
sparser
"The exact mechanism by which Tax inactivates A20 has remained elusive."
21765415
sparser
"HTLV-1 Tax might also provide a bridge to the proteasome by disrupting the interaction between an E3 ubiquitin ligase and its substrate, illustrated by the inactivation by Tax of the A20-Itch E3 ligase complex, potentially leading to a permanent activation of tumor necrosis factor (TNF) receptor (TNFR) signaling [ xref ]."
22458338
sparser
"CADM1 is required for Tax to inactivate the A20 complex."
25774694
sparser
"Tax inactivation of A20 alleviates the negative feedback control of NF-κB and facilitates persistent NF-κB signaling that drives cell transformation."
25341660