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Hydroxychloroquine increases the amount of IL1B. 3 / 3
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"Thus, HCQ completely wiped out the effectiveness of DAPA.While HCQ co-treatment tended to increase expression of Kim1, Il1b, Cd68, and Col3a1 it significantly increased expression of Nlrp3, Il6, Ccl2, Tnfα, Emr1, Tgfb1, Col1a1, and Spp1 (p = 0.0317, 0.0382, 0.0159, 0.0317, 0.0159, 0.0317, 0.0159, 0.0159, Mann–Whitney U test) (Fig. 6a–i and Supplementary Figure S8)."
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"Among the three groups receiving different doses, the 5 and 10 µM HCQ groups did not exhibit a noticeable downregulation effect on pyroptosis-related proteins, whereas HCQ at a concentration of 20 µM significantly decreased NLRP3 levels and suppressed the expression of GSDMD and the inflammatory factor IL-1β, as shown in Figure 7B–E. Finally, immunofluorescence staining was employed to detect the fluorescence expression of NLRP3 (green) in microglial cells activated after LPS + OGD treatment and treated with 20 µM HCQ."