IndraLab

Statements


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"Although serum MCP-1 and MIF concentrations were not changed by either statins, atorvastatin administration increased PPAR-alpha and -gamma mRNA abundances and decreased NF-kappaB p50, p65, MCP-1 and TNF-alpha mRNA abundances in atherosclerotic lesions."

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"Atorvastatin inhibits activation of NFkappaB3 and p65 (RELA) XREF_BIBR, XREF_BIBR, NFkappaB complex XREF_BIBR, XREF_BIBR and STAT1 XREF_BIBR which are transcription factors that activate the transcription of CXCL10 gene to mRNA XREF_BIBR - XREF_BIBR (XREF_FIG)."

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"Furthermore, atorvastatin also inhibited the expression of TLR4/MyD88/NF-κB pathway-related proteins (TLR4, MyD88, and p-NF-κB p65)."

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"Atorvastatin inhibits TREM-2, NF-kappaB p65, and p-IkappaB-alpha protein expression in OVA induced asthmatic mouse lungs."