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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

BBR inhibits COPS5. 3 / 3

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"In the present study, we found BBR specific binds to and inhibits the activity of CSN5, leading to ubiquitination and subsequent degradation of PD-L1."

33354502

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"To further confirm BBR directly binds to and inactivates CSN5, a molecular docking model of BBR with crystal structure of CSN5 (PDB ID : 5JOG) was established."

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"Our findings show that BBR inhibited CSN5 activity and reduced PD-L1-based immunosuppression."

33354502

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Statements

BBR inhibits COPS5. 3 / 3

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