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BBR inhibits COPS5. 3 / 3

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"In the present study, we found BBR specific binds to and inhibits the activity of CSN5, leading to ubiquitination and subsequent degradation of PD-L1."

33354502

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"To further confirm BBR directly binds to and inactivates CSN5, a molecular docking model of BBR with crystal structure of CSN5 (PDB ID : 5JOG) was established."

33354502

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"Our findings show that BBR inhibited CSN5 activity and reduced PD-L1-based immunosuppression."

33354502

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IndraLab

Statements

BBR inhibits COPS5. 3 / 3

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