IndraLab

Statements

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"Owing to its relationship with the chemotherapeutic resistance of several types of human cancers (Glinsky, 2005), cyclin B1 may also mediate the USP22 induced MDR in HCC cells, which is valuable for future exploration."
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"These results confirmed the role of SIRT1 in USP22 induced MDR in HCC cells."
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"] Our previous work revealed that USP22 was able to promote HCC stemness by a HIF1alpha / USP22 positive feedback loop and mediate multidrug resistance ( MDR ) by activating the SIRT1 / AKT / MRP1 pathway ."
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"XREF_BIBR Ubiquitin specific protease 22 (USP22) mediates the MDR of HCC via the SIRT1/AKT/MRP1 signaling pathway."
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"Simply put, USP22 may activate the SIRT1–AKT–MRP1 pathway and consequently promote MDR in human HCC cells (226)."
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"First, we defined SIRT1 as a significant mediator in USP22 driven MDR in HCC."
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"Together, these results indicate that USP22 could promote the MDR in HCC cells by activating the SIRT1/AKT/MRP1 pathway."
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"Taken together, the present study found that USP22 can promote the MDR in HCC cells via activating the SIRT1/AKT/MRP1 pathway."
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"Interestingly, we found that modulation of USP22 or SIRT1 could influence the intracellular ADR concentration, which might partly bridge the induction of MDR by USP22 and SIRT1 in HCC cells."
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