IndraLab

Statements

USP19 binds UFM1. 7 / 7
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"UFM1 interacts with and regulates USP19."
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"The result suggests USP19 as a rating limiting factor in UFMylation-dependent UcPS: Only in USP19 high cells, increased UFMylation can lead to more secretion, demonstrating a functional interplay between USP19 and UFM1 in UcPS.We next explored the possibility that USP19 might directly bind UFM1."
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"We next explored the possibility that USP19 might directly bind UFM1."
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"Pull-down using glutathione S -transferase (GST)–UFM1 fusion protein as a bait and GST as a negative control showed that USP19 CS readily coprecipitated with UFM1, whereas USP19 CD only weakly bound to UFM1 ( xref )."
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"The interaction of UFM1 with USP19 further supported their coordinated action in the misfolding-associated protein secretion pathway (Wang et al., 2024a)."
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"Although these methods failed to detect an interaction between USP19 ΔTM and UFM1 ( xref and fig."
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"Furthermore, cross-linking–based immunoprecipitation using HEK293T cells expressing FLAG-tagged USP19 revealed an interaction between full-length USP19 and endogenous UFM1 (fig."
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