IndraLab

Statements

K27 binds UCHL3. 5 / 5
| 5
sparser
"Furthermore, we showed that UCHL3 preferentially binds to K27 diUb and that its catalytic site is important for regulating K27 polyUb chains in cells."
28190767
sparser
"Further studies on the interaction between UCHL3 and K27 diUb by Pan et al. revealed an unique inhibition mechanism where the crossover loop of UCHL3 binds between the two Ub moieties putting UCHL3 in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34961664
sparser
"We decided to further investigate the detected selective interaction between UCHL3 and K27 diUb."
28190767
sparser
"We confirmed a direct interaction between UCHL3 and both non-hydrolyzable and native K27 diUb ( Figures 5 E and 5F)."
28190767
sparser
"Previous studies have analyzed the crystal structure of UCHL3-K27 di-Ub, in which one ubiquitin occupies the S1 site of UCHL3 and the other ubiquitin occupies the S2 site of UCHL3 ( xref A) [ xref ]."
36142702