IndraLab

Statements

Curcumin inhibits RELA. 50 / 52
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"The supershift assay showed that TNFalpha increases neuroblastoma NF-kappaB activity through the canonical pathway, specifically through increases in the p50 and p65 subunits; curcumin blocked the p50 and p65 subunit activation as seen by antibody shift (XREF_FIG)."
22284765
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"Moreover, the nuclear NF-kappaB and p65 protein abundance were also decreased by curcumin."
27297427
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"In addition, curcumin reduced the expression of the positive regulators of DNMT1, p65 and Sp1, which correlates with reductions in the binding of these transcription factors to the DNMT1 promoter in AML cell lines, demonstrating the promise of curcumin as a potential treatment for AML [XREF_BIBR]."
26457241
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"Curcumin also suppressed NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR) 1, TNFR2, NF-kappaB-inducing kinase, IkappaB kinase complex (IKK), and the p65 subunit of NF-kappaB."
16219905
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"Finally, curcumin tended to decrease p65 nuclear localization at 50 microM (p> 0.05 vs. vehicle + LPS)."
22197802
eidos
"On the other hand , curcumin and curcumin-Cu2 + or - Zn2 + complexes increased the Bcl-2 / Bax ratio , and reduced the level of NF-kappaB p65 , demonstrating that curcumin suppresses apoptosis ."
| PMC
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"Additionally, curcumin reduced the nuclear localization of p65."
27777559
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"However, translocation of NF-kappaBp65 was markedly blocked in the mice treated with DSS plus nanoparticle curcumin."
28985227
ctd
No evidence text available
16173963
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"Curcumin inhibits p65 and cell invasion by downregulation of COX-2 and MMP-2 expression [XREF_BIBR]; by suppression of gene expression of EGFR and modulation of Akt and mTOR signaling, and inhibition of cell growth [XREF_BIBR, XREF_BIBR]."
22583408
ctd
No evidence text available
18226269
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"Additionally, they found that curcumin can suppress the proliferation and invasive ability of tumor cells by targeting Smad4, NFκB p65, and cyclin D3 (regulatory factor of G1 to S phase of the cell cycle) genes through increasing the expression level of hsa-miR-138 [70]."
34671398
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"Results confirmed that curcumin attenuates activation of beta-catenin and NFkappaBp65 and reduces relative expression of stem cell markers."
24626093
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"To investigate the role of NF-kappaB in modulating cell survival, both the pharmacological inhibitor of NF-kappaB, curcumin, and RNA interference targeting p65 were used in the current study."
18811964
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"The present data show that curcumin prevented the activation of c-Rel and p65, which is essential for TF gene activation in endothelial cells, by impairing the proteolytic degradation inhibitor protein, I kappa B alpha."
9437186
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"Curcumin also reduced NF-kappaB transcriptional factor RELA (p65), as well as oncogenic STAT3 and EGFR mRNAs in neutral bile, acid alone and neutral control treated cells (P <.01, by t test; means +/-SD; multiple comparisons by Holm-Sidak)."
29911313
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"Compared to controls, the presence of p65 in the nuclear fraction was markedly decreased in cells treated with curcumin alone or with curcumin and docetaxel (XREF_FIG)."
24741455
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"Curcumin completely abolished a hyperosmoticity induced increase of NF-kappaB p65."
20026325
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"Moreover, curcumin was proved to suppress the p38, JNK and NF-kappaB p65 in human intestinal epithelial HT29 cell line."
20885979
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"Correspondingly, we found that radiation induced increased NF-kappaB p65 immunoreactivity was decreased by curcumin (XREF_FIG)."
23946685
ctd
No evidence text available
18640131
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"As shown in XREF_FIG, curcumin treatment for 24 h time-dependently reduced the activation of different NF-kappaB subunits (p50 and p65)."
25431425
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"Curcumin treatment blocked activation of p50 and p65, which was significantly activated by pretreatment with 1 muM PGE 2 for 2 h (XREF_FIG)."
25431425
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"As shown in XREF_FIG, levels of nuclear p65 were decreased in all cases when HT29 cells were treated with OXA plus Curcumin as compared with OXA alone."
27091625
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"In MDA-MB-231 cells, curcumin inhibited NF-kB p65, triggering apoptosis [79]."
| PMC
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"They have concluded that curcumin reduced the expression and transcriptional activity of NF-kappaB p65 protein and decreased the levels of the Recepteur d'Origine Nantais tyrosine kinase (RON) [XREF_BIBR]."
27834913
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"Both the pharmacologic inhibitor of NF-kappaB, curcumin, and RNA interference targeting p65 were used to block NF-kappaB signaling in HBECs."
18811964
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"Curcumin prevents NF- kappaB and p65 phospohorylation at serine 536 and its acetylation through p300 inhibition [XREF_BIBR]."
25152696
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"This high dose could be a more effective dose of curcumin supplementation to reduce the diabetes induced vascular NF-kappaB p65 and COX-2 upregulation."
21437112
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"Curcumin blocks the positive regulators of DNMT1, p65 and Sp1 decreasing their activity for binding to the promoter region of DNMT1."
30881375
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"Curcumin supplementation in Hp + curI and Hp + curII groups significantly decreased NF-kappaB p65 immunoreactive cells and macromolecular leakage compared with results in the Hp group."
20731017
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"We found that NF-kappaB was constitutively active in all human MM cell lines examined and that curcumin, a chemopreventive agent, down-regulated NF-kappaB in all cell lines as indicated by electrophoretic mobility gel shift assay and prevented the nuclear retention of p65 as shown by immunocytochemistry."
12393461
ctd
No evidence text available
16023083
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"RT-qPCR, IHC staining and Western blot showed that curcumin and A13 treatment could inhibit the NF-kappaB p65 pathway."
33602334
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"Mechanistically, curcumin reduced the expression of positive regulators of DNMT1, p65 and Sp1, which correlated with a reduction in binding of these transcription factors to the DNMT1 promoter in AML cell lines."
23457487
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"Our findings indicate that curcumin can effectively lower the elevated levels of HIF-1alpha and nuclear p65 (Rel A) in breast and lung cancer cells under a hypoxic tumour micro-environment when delivered in nanoparticulate form."
29065834
ctd
No evidence text available
18593918
ctd
No evidence text available
12216086
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"I kappa B alpha, a previously identified NF-kappa B inducible gene, was overexpressed in human pancreatic tumor tissues and cell lines, and RelA activation could be inhibited by curcumin and dominant negative mutants of I kappa B alpha, raf, and MEKK1."
9918209
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"However, pretreatment with PGE 2 attenuated curcumin induced inhibition of p50, p65, and RelB of NF-kappaB signaling (XREF_FIG)."
25431425
eidos
"However , in MCF-7 / LCC9 cells , curcumin slightly suppressed p65 expression but abolished its phosphorylation ."
23299550
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"Because treatment of septic rats with curcumin in vivo reduced NF-kappaB and p65 activity in skeletal muscle (XREF_FIG), we tested whether a similar mechanism may be involved in the direct effect of curcumin in septic muscle."
18389075
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"In addition, the RT-PCR analysis revealed that curcumin suppressed the macrophage marker F4/80, dendritic cell and M1 macrophage marker CD11c and oxidative stress sensitive transcription factor NF-kappaB p65 (encoded by Rela; Fig."
29899429
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"We provide evidence that curcumin suppresses p65, a transcription factor known to regulate FABP5."
25260874
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"Furthermore, curcumin substantially suppressed the expression of the oxidative stress inducible transcription factor NF-kappaB p65 and NF-kappaB-regulated ALOX5 in eWAT of obese mice XREF_BIBR - XREF_BIBR."
29899429
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"Curcumin analog A13 delayed histological lesions and inhibit NF-kappaB p65 pathway in the brain of diabetes rats."
33602334
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"Compared with the LPS group, p65 was down-regulated by curcumin, with statistically significant difference (P < 0.05)."
27916071
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"In addition, curcumin inhibits NF- κ B p65 activation and apoptosis by regulating ERK/JNK signaling pathway."
35711494
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"Curcumin and PGV-1 but not PGV-0 decreased localization of p65 into the nucleus induced by Dox, indicating that activation of NF- kB was inhibited."
24528023
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"Furthermore, combined curcumin and resveratrol significantly inhibited TNF-α-induced nuclear factor-kappaB (NF-κB) p65 nuclear protein expression than that by the individual chemical alone in EA.hy 926 cells, indicating that the synergistic effect of the combination may result from that curcumin reduces the required minimum concentration for resveratrol to inhibit the nuclear translocation of NF-κB."
35691595