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Curcumin inhibits RELA. 61 / 80
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"In addition, the RT-PCR analysis revealed that curcumin suppressed the macrophage marker F4/80, dendritic cell and M1 macrophage marker CD11c and oxidative stress sensitive transcription factor NF-kappaB p65 (encoded by Rela; Fig."
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"Furthermore, curcumin substantially suppressed the expression of the oxidative stress inducible transcription factor NF-kappaB p65 and NF-kappaB-regulated ALOX5 in eWAT of obese mice XREF_BIBR - XREF_BIBR."
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"As shown in XREF_FIG, levels of nuclear p65 were decreased in all cases when HT29 cells were treated with OXA plus Curcumin as compared with OXA alone."
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"The results demonstrated that pretreatment of HepG2 cells with curcumin decreased nuclear localization of p65 in infected cells."
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"Curcumin treatment blocked activation of p50 and p65, which was significantly activated by pretreatment with 1 muM PGE 2 for 2 h (XREF_FIG)."
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"As shown in XREF_FIG, curcumin treatment for 24 h time-dependently reduced the activation of different NF-kappaB subunits (p50 and p65)."
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"However, pretreatment with PGE 2 attenuated curcumin induced inhibition of p50, p65, and RelB of NF-kappaB signaling (XREF_FIG)."
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"Curcumin also reduced the nuclear accumulation of p65 subunit at a concentration of 10 mM during the 60-min time course upon LPS induction."
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"Because treatment of septic rats with curcumin in vivo reduced NF-kappaB and p65 activity in skeletal muscle (XREF_FIG), we tested whether a similar mechanism may be involved in the direct effect of curcumin in septic muscle."
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"Chromatin immunoprecipitation results showed that curcumin reduced the binding of NFκB p65 on Bcl-2 and Mcl-1 promoters ( Fig. 3 C)."
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"Curcumin also reduced NF-kappaB transcriptional factor RELA (p65), as well as oncogenic STAT3 and EGFR mRNAs in neutral bile, acid alone and neutral control treated cells (P <.01, by t test; means +/-SD; multiple comparisons by Holm-Sidak)."
29911313
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"Curcumin inhibits p65 and cell invasion by downregulation of COX-2 and MMP-2 expression [XREF_BIBR]; by suppression of gene expression of EGFR and modulation of Akt and mTOR signaling, and inhibition of cell growth [XREF_BIBR, XREF_BIBR]."
22583408
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"Curcumin and PGV-1 but not PGV-0 decreased localization of p65 into the nucleus induced by Dox, indicating that activation of NF- kB was inhibited."
24528023
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"On the other hand , curcumin and curcumin-Cu2 + or - Zn2 + complexes increased the Bcl-2 / Bax ratio , and reduced the level of NF-kappaB p65 , demonstrating that curcumin suppresses apoptosis ."
| PMC
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"The supershift assay showed that TNFalpha increases neuroblastoma NF-kappaB activity through the canonical pathway, specifically through increases in the p50 and p65 subunits; curcumin blocked the p50 and p65 subunit activation as seen by antibody shift (XREF_FIG)."
22284765
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"However , in MCF-7 / LCC9 cells , curcumin slightly suppressed p65 expression but abolished its phosphorylation ."
23299550
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"The present data show that curcumin prevented the activation of c-Rel and p65, which is essential for TF gene activation in endothelial cells, by impairing the proteolytic degradation inhibitor protein, I kappa B alpha."
9437186
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"More importantly, curcumin downregulated NF-ĸB transcription factors, c-REL, p65, anti-apoptotic Bcl-2, oncogenic TNF-α and STAT3."
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"Additionally, curcumin reduced the nuclear localization of p65."
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"Moreover, the nuclear NF-kappaB and p65 protein abundance were also decreased by curcumin."
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"They have concluded that curcumin reduced the expression and transcriptional activity of NF-kappaB p65 protein and decreased the levels of the Recepteur d'Origine Nantais tyrosine kinase (RON) [XREF_BIBR]."
27834913
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"Results confirmed that curcumin attenuates activation of beta-catenin and NFkappaBp65 and reduces relative expression of stem cell markers."
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"Moreover, curcumin was proved to suppress the p38, JNK and NF-kappaB p65 in human intestinal epithelial HT29 cell line."
20885979
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"I kappa B alpha, a previously identified NF-kappa B inducible gene, was overexpressed in human pancreatic tumor tissues and cell lines, and RelA activation could be inhibited by curcumin and dominant negative mutants of I kappa B alpha, raf, and MEKK1."
9918209
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"Previously, we showed that a diet supplemented with 10 or 15 g/kg curcumin downregulated NF-κB p65 , IL-1β , and TNF-α in the head kidney and hepatopancreas of C. carpio [ 54 ]."
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"Pretreatment with 5 μM of curcumin inhibited hyperosmoticity-induced increase of NF-κB p65 by 48.40%, while pretreatment with 20 μM of p38 inhibitor SB 203580 inhibited increase of NF-kB p65 by 49.12%[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that NF-kappaB was constitutively active in all human MM cell lines examined and that curcumin, a chemopreventive agent, down-regulated NF-kappaB in all cell lines as indicated by electrophoretic mobility gel shift assay and prevented the nuclear retention of p65 as shown by immunocytochemistry."
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"This indicates that hyperosmoticity-induced increase of IL-1β is dependent on the activation of NF-κB. Curcumin completely abolished the increase of NF-κB p65 caused by hyperosmotic culture medium."
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"We provide evidence that curcumin suppresses p65, a transcription factor known to regulate FABP5."
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"Treatment of infected cells with curcumin downregulated accumulation of ROS in infected cells, decreased nuclear accumulation of p65 and p53, and decreased gene expression profiles of the inflammatory[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Correspondingly, we found that radiation induced increased NF-kappaB p65 immunoreactivity was decreased by curcumin (XREF_FIG)."
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"Additionally, they found that curcumin can suppress the proliferation and invasive ability of tumor cells by targeting Smad4, NFκB p65, and cyclin D3 (regulatory factor of G1 to S phase of the cell cycle) genes through increasing the expression level of hsa-miR-138 [70]."
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"Curcumin also suppressed NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR) 1, TNFR2, NF-kappaB-inducing kinase, IkappaB kinase complex (IKK), and the p65 subunit of NF-kappaB."
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"Our findings indicate that curcumin can effectively lower the elevated levels of HIF-1alpha and nuclear p65 (Rel A) in breast and lung cancer cells under a hypoxic tumour micro-environment when delivered in nanoparticulate form."
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"Curcumin prevents NF- kappaB and p65 phospohorylation at serine 536 and its acetylation through p300 inhibition [XREF_BIBR]."
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"However, translocation of NF-kappaBp65 was markedly blocked in the mice treated with DSS plus nanoparticle curcumin."
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"To investigate the role of NF-kappaB in modulating cell survival, both the pharmacological inhibitor of NF-kappaB, curcumin, and RNA interference targeting p65 were used in the current study."
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"RT-qPCR, IHC staining and Western blot showed that curcumin and A13 treatment could inhibit the NF-kappaB p65 pathway."
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"Curcumin analog A13 delayed histological lesions and inhibit NF-kappaB p65 pathway in the brain of diabetes rats."
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"In addition, curcumin reduced the expression of the positive regulators of DNMT1, p65 and Sp1, which correlates with reductions in the binding of these transcription factors to the DNMT1 promoter in AML cell lines, demonstrating the promise of curcumin as a potential treatment for AML [XREF_BIBR]."
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"Curcumin supplementation in Hp + curI and Hp + curII groups significantly decreased NF-kappaB p65 immunoreactive cells and macromolecular leakage compared with results in the Hp group."
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"Compared with the LPS group, p65 was down-regulated by curcumin, with statistically significant difference (P < 0.05)."
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"In MDA-MB-231 cells, curcumin inhibited NF-kB p65, triggering apoptosis [79]."
| PMC
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"Consistently, using luciferase reporter gene assay, both BHMC and curcumin significantly suppressed p65 NF-κB transcriptional activity at 12.5 μM ( P <0.005) ( Fig. 5 C)."
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"In addition, immunofluorescence analysis of RelA revealed that curcumin repressed the increased nuclear localization of RelA in the cells transfected with Otud7b-siRNAs (Figure 6C)."
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"The results demonstrate that curcumin prevented the nuclear-retention of p65 in SP-53 cell lines ( Fig. 3 E)."
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"Besides the effects of curcumin on decreasing pro-inflammatory molecules such as IL-6 and IL-8, curcumin-induced p65 inhibition is causing a reduction in senescence-associated secretory phenotype (SASP) in mesenchymal stem cells which restores the function and the inflammation-aging signature of these cells (Mato-Basalo et al., 2021)."
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"Cao et al. reported that curcumin significantly reduced the elevated expression of NF-κB p65 and CX3CR1 in the spinal cord and dorsal root ganglion (DRG) and alleviated CCI-induced neuropathic pain (Cao et al. 2014)."
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"This high dose could be a more effective dose of curcumin supplementation to reduce the diabetes induced vascular NF-kappaB p65 and COX-2 upregulation."
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"In addition, immunofluorescence analysis of RelA revealed that curcumin repressed the increased nuclear-to-cytoplasmic ratio of RelA in the cells transfected with Otud7b-siRNAs (Figures 6C and S5L)."
38510130
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"Similar to the results for curcumin, BMS-345541 also repressed the increased nuclear localization of RelA in the cells transfected with Otud7b-siRNAs (Figure 6F)."
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"Compared to controls, the presence of p65 in the nuclear fraction was markedly decreased in cells treated with curcumin alone or with curcumin and docetaxel (XREF_FIG)."
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"Furthermore, curcumin was found to suppress p38 MAPK activity and heat-inducedNF-kB p65 activity, which indicates that curcumin may be an effective analgesic for thermal injury pain through suppression of inflammation at the site of injury."
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"Curcumin blocks the positive regulators of DNMT1, p65 and Sp1 decreasing their activity for binding to the promoter region of DNMT1."
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"However, curcumin and 44 also decreased the localization of p65 into the nucleus induced by doxorubicin, indicating the inhibition of HER2 activity and NF-κB activation."
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"In addition, curcumin inhibits NF-kappaB p65 activation and apoptosis by regulating ERK/JNK signaling pathway."
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"Finally, curcumin tended to decrease p65 nuclear localization at 50 microM (p> 0.05 vs. vehicle + LPS)."
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"The results showed that the curcumin just decrease the nuclear p65 ( Fig. 5 B), but not the total p65 ( Fig. 5 C), which are consistent with the curcumin-induced NF-κB inhibition as revealed by the EM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin Inhibits NF-kappaB p65 Activation and Apoptosis by Regulating ERK/JNK Signaling Pathway."
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"After a subarachnoid hemorrhage (SAH), curcumin treatment through intraperitoneal injection significantly reduced the expression of TLR4, MyD88, NF-κB p65, and phosphorylated IκBα, causing the phenoty[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, curcumin inhibited NF-κB p65 activation and apoptosis by regulating ERK/JNK signaling pathway."
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