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USP33 deubiquitinates JAK2. 3 / 3
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"From the UbiBrowser _V2 data, we found that JAK2 was a potential target for USP33, suggesting that USP33 probably participated in the deubiquitination of JAK2 protein (Fig. 5A)."
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"Further in vivo ubiquitination assay verified that USP33 overexpression significantly decreased JAK2 ubiquitination compared with the control group (Fig. 5C)."
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"All those results demonstrated that USP33 overexpression activated JAK2/STAT3 signaling pathway through deubiquitinating JAK2."
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