IndraLab

Statements

LEF1 binds OTUD7B. 11 / 11
2 | 3 6
sparser
"OTUD7B and LEF1 interact with each other through the UBA and HMG domains, respectively."
37371581
sparser
"LEF1 Interacts with OTUD7B through the HMG and UBA Domains, Respectively."
37371581
sparser
"The interaction between LEF1 and OTUD7B occurs through the HMG and UBA domains of LEF1 and OTUD7B, respectively."
37371581
sparser
"To determine which domains are responsible for the interaction between LEF1 and OTUD7B, we generated three deletion mutants of LEF1: LEF1ΔHMG (High Mobility Group domain deleted, aa 1-804), LEF1ΔCRD (context-dependent regulatory domain deleted, aa 1-201 & 805-1116), and LEF1ΔBCBD (β-catenin binding domain deleted, aa 202-1116) ( xref A) using the MYC-LEF1 plasmid."
37371581
biogrid
No evidence text available
37371581
biogrid
No evidence text available
37371581
reach
"To determine which domains are responsible for the interaction between LEF1 and OTUD7B, we generated three deletion mutants of LEF1: LEF1ΔHMG (High Mobility Group domain deleted, aa 1-804), LEF1ΔCRD (context-dependent regulatory domain deleted, aa 1-201 & 805-1116), and LEF1ΔBCBD (β-catenin binding domain deleted, aa 202-1116) (Figure 2A) using the MYC-LEF1 plasmid."
37371581
reach
"This result suggests that LEF1 binds to OTUD7B through its N-terminus, which contains the UBA domain."
37371581
sparser
"As shown in xref D, the full-length OTUD7B and all three mutant forms interacted with LEF1."
37371581
sparser
"This result suggests that LEF1 binds to OTUD7B through its N-terminus, which contains the UBA domain."
37371581
reach
"The interaction between LEF1 and OTUD7B occurs through the HMG and UBA domains of LEF1 and OTUD7B, respectively."
37371581