IndraLab

Statements

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"We showed that OTUB2 prevents cancer stemness via elevated OXPHOS and subsequently increased PS synthesis."
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"Furthermore, treatment of cells with the Ca 2+ channel inhibitor ruthenium red completely abolished the elevated PS synthesis triggered by OTUB2 or CALML3 overexpression ( Figure S3 H), proving the cr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further lipidomic analyses indicated that OTUB2/STAT1 promoted phosphatidylserine (PS) synthesis by activating calmodulin-like protein 3 ( CALML3 )."
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"We next detected intracellular PS levels using ELISAs, and the results showed that OTUB2 significantly elevated the total PS content in a CALML3-dependent manner ( Figures 3 E and 3F)."
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