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TNF binds IL1R1. 24 / 24
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"On the other hand, we found that minocycline prominently blunted the prenatal LPS-induced Etd uptake in hippocampal astrocytes, whereas pretreatment with a soluble form of TNF-α receptor that binds TNF-α (sTNF-aR1) and a recombinant antagonist for IL-1β receptor (IL-1ra) caused equivalent responses (Figure 2Q)."
31680871
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"IL-1 and TNFα bind to their receptors IL-1R and TNFR1 and promote the classical activation of the NFκB pathway, which involves the phosphorylation and subsequent degradation of inhibitor of κB (IκB) p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38443222
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"The target genes of TLR pathways increase in traumatically injured brains, including Ccl-2, granulocyte-colony stimulating factor (Csf3), IL-10, IL-1a, IL-1b, IL1r1, IL-6, TNF, Tnfrs1a, CCAAT/enhancer[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30075158
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"NF-κB transcriptional activity is carefully inhibited by binding to IκB in an inactive condition, while costimulating molecules, such as LPS, TNF-α bind to receptors TLRs, TNFRs, and IL-1R, which can lead to the IKKβ complex phosphorylating the inhibitory IκB proteins."
36500336
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"TNFalpha binding to TNFRs or IL-1 binding to IL-1R can activate NF-kappaB signaling and transcription of NF-kappaB target genes [XREF_BIBR], evidence of which we observed here."
20097302
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"On the other hand, application of IL-1ra or TNF binding protein to diet treated ApoE -/- mice resulted in reduced lesion area."
21199323
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"In another study, young men (N = 30) were randomly assigned to a typhoid vaccination or a placebo control (Wright et al., 2005) and the associations between state PA and IL-1ra, IL-6, and TNF-α were examined; PA was assessed at baseline and then 1.5, 3, and 6 h post-injection and inflammatory markers were assessed at baseline and 3 h post-injection."
33130406
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"After pathogens infection, IL-1 and TNFα bind to the receptors IL-1R and TNFR, respectively, and they trigger the activation of different signalling cascades that coalesce on TGF-β-activated kinase 1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36174908
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"Our study confirms the association of SNPs IL1R1 (rs2234650) and TNFA (rs1800629) with risk of vertical transmission."
30109734
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"In the case of RIP and IL-1 receptor associated kinase (IRAK), kinases that are part of the TNF- and IL-1R complex, respectively, the essential role suggested for these molecules in TNF and IL-1 signa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11384837
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"Here we report that blockade of IL-1alpha and beta and TNFalpha binding to IL-1R and TNFR1, respectively, reduced neuropathology in parietal cortex, hippocampus, and thalamus and improved outcome."
26172557
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"Previous studies reported that IL1beta and TNFalpha exert toxic effects by binding to their cognate receptors, IL1-R1 and TNFR1, respectively, triggering downstream signaling pathways that activate transcription factors, such as NFkappaB or AP1 which in turn lead to the production of NO and ROS."
19526281
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"Immunofluorescence staining and the proximity ligation assay (PLA) were performed to evaluate bindings of TNF-alpha, IL-1beta, and IL-6 to TNFR1, IL-1R, and IL-6R, respectively, in liver tissues, per a previously reported method [XREF_BIBR]."
| PMC
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"The binding of TNF to p60 or p80 receptor was determined by preincubating the cells at 37 C for 1 h with 0.6-0.8 / < g/ml of either preimmune or anti-p60 or anti-p80 antibodies before initiating the 0[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8276122
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"In the present study, the PLA data indicated that KCF18 could simultaneously inhibit more than 70% binding of TNF-alpha to TNFR1, more than 80% binding of IL-1beta to IL-1R, and approximately 70% binding of IL-6 to IL-6R in the liver tissues of mice with endotoxemia."
| PMC
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"Likewise, a soluble TNF-α receptor that binds TNF-α (sTNF-aR1) and an IL-1β receptor antagonist (IL-1ra) significantly suppressed the Etd uptake triggered by ethanol (Fig. 4A)."
38576018
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"XREF_BIBR We have earlier found bivariate associations between trauma and IL-1RA and TNF-alpha in a cross-sectional assessment, XREF_BIBR and we decided to explore these relationships longitudinally."
30271153
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"Then the cells were resuspended in essential medium at a concentration of 5 x lO '/ml and incubated for another 16 h at 37 C. Thereafter specific TNF binding to p60 and p80 was determined as described[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8397114
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"These cytokines and their receptors have also been reported to be involved in bone loss after estrogen deficiency : for instance, administration of IL-1Ra and TNF binding protein (TNFbp), an inhibitor of TNF, to ovariectomized mice decreased osteoclastogenesis and bone resorption [XREF_BIBR]."
12823855
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"The interaction between IL-1RA +2018 and TNF-α-238 showed a strong independent association between each SNP and silicosis, which may be attributed to the overlapping functions of inflammatory cytokines (23)."
40182855
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"IL-1 and TNF-alpha bind to their respective receptors, IL-1R and TNFR, and trigger activation of diverse signaling cascades that converge at TGF-alpha activated kinase 1 (TAK1), which phosphorylates and activates IKK."
25396681
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"IL-1 and TNFalpha bind to the receptors IL-1R and TNFR, respectively, and trigger activation of distinct signaling cascades that converge on TGF-beta activated kinase 1 (TAK1), which phosphorylates and activates IKK, leading to activation of NF-kappaB (XREF_FIG) [XREF_BIBR]."
23312890
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"This included determination of the levels of IL-1 beta and TNF-alpha receptor binding, IL-1Ra and TNF-soluble receptors 55 and 75 (TNF-sR55 and TNF-sR75)."
9616438
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"In addition to the conditional associations between TNF-α, IL-1RA, IL-6, and composite scores and NAPI MDV and AO scores, there were also multiple interaction effects for various cytokines and either PMA at birth or infant sex on NAPI outcomes."
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