IndraLab

Statements

His-Ser inhibits CASP1. 7 / 7
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"HS inhibits 5-FU-mediated caspase-1 activation in vitro and in vivo without affecting its cytotoxicity on MDSCs."
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"We show here that HS is able to inhibit caspase-1 activation in MDSCs and tumor growth and conversely that HSP70 deficiency increases caspase-1 activation in MDSCs and accelerates tumor growth in a murine preclinical model."
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"Because HS inhibits caspase-1 activation in MDSCs, we investigated its effects on tumor growth, in mice subcutaneously injected with EL4 tumor cells."
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"However, HS inhibited 5-FU-mediated caspase-1 activation (XREF_FIG)."
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"Altogether, our results show that HS is able to inhibit 5-FU-mediated caspase-1 activation without affecting 5-FU MDSC killing."
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"However, a HS leading to HSP70 expression inhibited the activation of caspase-1 and the release of active caspase-1 and mature IL-1beta (XREF_FIG)."
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"HS inhibits caspase-1 activation in MDSCs in vitro and in vivo."
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