
IndraLab
Statements
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2
eidos
"Lopinavir / ritonavir can increase levels of beta-blockers warranting ECG monitoring and , potentially , dose downtitration , while hydroxychloroquine and chloroquine may reduce levels of beta-blocker and require a dose uptitration.68Among mineralocorticoid receptor antagonists , spironolactone can be safely used with lopinavir / ritonavir , whereas eplerenone , which is mainly metabolized by CYP3A4 , should not be coadministered ."