IndraLab

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OTUB2 increases the amount of TAFAZZIN. 3 / 3
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"However, depletion of OTUB2 reduced the YAP/TAZ protein levels both in the wild-type and the LATS1/2 knockout cells, which was not due to changes of YAP/TAZ mRNA levels ( Figure 3 E; data not shown)."
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"Moreover, we detected strong YAP/TAZ protein levels in the metastatic nodules from the lung and brain of the OTUB2 group ( Figure 2 K), suggesting that OTUB2 can increase the levels of YAP/TAZ."
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"This phenomenon indicated that OTUB2 may promoting YAP1 and TAZ protein expression during the development of ESCC, and the role of OTUB2 in promoting the development of ESCC may mainly occur via YAP1 and TAZ."
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