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IHC decreases the amount of BAP1. 14 / 14
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"The melanomas that have been tested show biallelic BAP1 inactivation.34 One of the melanomas described in this setting arose in association with an epithelioid naevus (similar to those described above[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this pilot study, we inves- tigated whether loss of BAP1 expression by IHC is associated with prognosis in uveal melanoma patients."
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"The loss of BAP1 expression by IHC is a reliable tool to assess this molecular alteration."
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"Recently, loss of BAP1 (BRCA1-associated protein-1) expression by IHC, homozygous deletion of CDKN2A (p16) by FISH, and expression of methyl-thio-adenosine phosphorylase (MTAP) by IHC were added as markers to distinguish non-neoplastic from neoplastic cells when mesothelial proliferation is confined to the serosal surface."
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"In the current pilot study, we explored the hypothesis that loss of BAP1 expression by IHC is associated with prognosis in patients with uveal melanoma."
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"XREF_BIBR, XREF_BIBR Loss of PBRM1 or BAP1 expression by IHC is associated with a worse RCC specific survival in ccRCC supporting a role for distinguishing molecular subtypes of ccRCC."
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"Both the naevus and melanoma components showed loss of BAP1 expression by IHC, XREF_BIBR suggesting that some BAP1 mutated epithelioid melanocytic tumors may progress to melanoma."
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"In absence of invasion, loss of BAP1 expression by IHC and/or the presence of a homozygous deletion of CDKN2A (p16) by FISH or by methylthioadenosine phosphorylase (MTAP) IHC allow a differential diagnosis between neoplastic and non-neoplastic cells (16-18)."
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"Here we report loss of BAP1 expression by IHC in 61% of MPM cases overall, with 77% of epithelioid cases demonstrating BAP1 loss and retention in all of the sarcomatoid cases examined."
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"Our observation that a greater number of tumors exhibited loss of BAP1 protein expression by IHC compared with BAP1 deletions or mutations indicates that BAP1 may become functionally inactivated by mechanisms other than deletions or mutations in the coding region; for example, epigenetic changes leading to silencing of the BAP1 gene or other, yet to be identified, alterations that prevent BAP1 expression."
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"In this pilot study, we investigated whether loss of BAP1 expression by IHC is associated with prognosis in uveal melanoma patients."
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"In total, 178 (48%) cases showed loss of expression of BAP1 by IHC."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Given that real rate of germline BAP1 mutations is likely to be less than 1%, it is reasonable that formal genetic testing for BAP1 mutation be reserved for those patients who are considered high-risk based on family and personal history and demonstrate loss of BAP1 expression by IHC."
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"Loss of BAP1 Expression by IHC Identifies a Morphologically Distinct Subset of Tumors."
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