IndraLab

Statements

USP13 binds AAV9. 4 / 4
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"To achieve cardiomyocyte-specific overexpression of USP13 in vivo, we employed an AAV9 containing a cardiac-specific cTnT promoter component under which the vector of USP13 was placed (AAV9-USP13 oe ) while the AAV9-cTnT-vector used as a control (AAV9-Ctrl)."
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"The results revealed a pronounced increase in GPX4 and SLC7A11, along with a significant decrease in PTGS2, TNF and IL-6, in the AAV9-USP13 oe mice compared to the AAV9-Ctrl mice, while there was no substantial discrepancy in the expression of cleaved caspase-3. ( xref B through 7D and xref through S14D)."
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"Furthermore, Masson's trichrome staining revealed that AAV9-USP13 oe mice exhibited significantly reduced MI scar sizes compared with those of AAV9-Ctrl mice ( xref K and L)."
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"Ultrasound-guided, in situ multi-point injections of AAV9-USP13 oe were administered to mouse hearts."
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