IndraLab

Statements

Chloroquine inhibits IFNB1. 9 / 9
| 9
reach
"In contrast to USA300 XREF_BIBR, Ifnb induction by 502A was not inhibited by chloroquine, which indicated a lack of endosomal TLR involvement."
24586160
reach
"IFN-beta synthesis was strongly diminished by both dynasore and chloroquine treatments."
22432012
reach
"Chloroquine reduced IFN-beta mRNA at 24 h and more completely by 48 h (XREF_FIG) whereas IFN-lambda 1 was only inhibited by chloroquine at 48 h. However, chloroquine also inhibited viral replication at 24 and 48 h (XREF_SUPPLEMENTARY)."
23658644
reach
"Through in silico screening of the drug library, computational analysis confirmed that quinacrine and chloroquine are effective inhibitors of IFN-beta and act by inhibiting dsDNA stimulation of cGAS."
33688199
reach
"Supporting the specificity of dsRNA and LyoVec for RLRs, chloroquine (10 microg/ml) did not reduce IFN-beta or IFN-lambda 1 mRNA at 3 and 24 h (XREF_SUPPLEMENTARY)."
23658644
reach
"In our experiments, pre-treatment of PEM with either cytochalasin D, an inhibitor of actin polymerization and thus internalization, dynasore, an inhibitor of the endocytic effector dynamin, or chloroquine, which inhibits endosome acidification [30], [31], significantly impaired the induction of IFN-β following Listeria infection, strongly suggesting that phagocytosis of L. monocytogenes and intracellular location of TLR2 trigger this response."
22432012
reach
"IFN-β synthesis was strongly diminished by both dynasore and chloroquine treatments."
22432012
reach
"In our experiments, pre-treatment of PEM with either cytochalasin D, an inhibitor of actin polymerization and thus internalization, dynasore, an inhibitor of the endocytic effector dynamin, or chloroquine, which inhibits endosome acidification XREF_BIBR, XREF_BIBR, significantly impaired the induction of IFN-beta following Listeria infection, strongly suggesting that phagocytosis of L. monocytogenes and intracellular location of TLR2 trigger this response."
22432012
reach
"Chloroquine attenuates TLR3 and IFN-beta signaling in cultured normal human mesangial cells : A possible protective effect against renal damage in lupus nephritis."
28150518