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USP8 activates POMC promoter. 2 / 2

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"Ectopic expression of USP8 mutants or cleaved USP8 in murine corticotroph cell line induced higher POMC promoter activity and transcription than wild-type USP8."

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"In the absence of EGFR, USP8 was unable to augment the POMC promoter activity in luciferase reporter assay, and gefitinib, an EGFR inhibitor, significantly impaired the ACTH production in primary corticotroph adenoma cells [XREF_BIBR, XREF_BIBR]."

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USP8 activates POMC promoter. 2 / 2

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