IndraLab

Statements

COPS6 inhibits FBXW7. 5 / 5
| 5
reach
"Finally, to link CSN6 to the event, we showed that GSK3β (S9A)-enhanced FASN ubiquitination is attenuated by the expression of CSN6 (Fig. 4m), suggesting that CSN6 antagonized FBXW7β/GSK3β-mediated FASN ubiquitination.To determine the phenotypic effect of GSK3β in governing FBXW7β-mediated FASN degradation."
37202390
reach
"The significance of this interaction was demonstrated in that dox-induced CSN6 KD led to increased steady-state-expression of FBXW7β with concurrent decreased expression of FASN (Supplementary Fig. 3b), while CSN6 overexpression reduced FBXW7β and resulted in increased FASN level (Supplementary Fig. 3c)."
37202390
reach
"Further, CSN6 KD reduced the turnover rate of FBXW7β (Supplementary Fig. 3f), and overexpressing CSN6 increased the ubiquitination of FBXW7β (Supplementary Fig. 3g)."
37202390
reach
"In mouse experiments, Chen et al[20] demonstrated that COPS6 enhances Fbxw7 degradation through binding, thereby maintaining Myc stability and promoting tumor progression."
38059183
reach
"Notably, CSN6 negatively regulates FBXW7β through enhancing FBXW7β autoubiquitination, thereby stabilizing FASN."
37202390