IndraLab

Statements

USP1 activates BRCA1. 4 / 4
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"In contrast to the overexpression, the depletion of USP1 increased the number of BRCA1 foci but decreased the number of RIF1 foci in S/G2 cells (XREF_FIG, XREF_SUPPLEMENTARY)."
28604711
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"As expected, the number of BRCA1 foci reduced dramatically in Cdh1 depleted cells treated with HU, and the simultaneous depletion of USP1 with that of Cdh1 essentially restored BRCA1 focus number (XREF_FIG)."
28604711
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"As shown in XREF_FIG, the depletion of USP1 in control cells (no ectopic USP1 expression) expectedly caused an increase of BRCA1 IRIF but a decrease of RIF1 IRIF (as seen in XREF_FIG)."
28604711
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"Knockdown or inhibition of USP1 resulted in replication fork destabilization and decreased viability of BRCA1 deficient cells, revealing a synthetic lethal relationship."
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