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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CASP8 decreases the amount of CYLD. 2 / 6

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"Levels of CYLD may be indirectly increased by allosteric inhibition of caspase 8 (which cleaves CYLD) by zVAD-FMK [XREF_BIBR]."

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"Blockade of Caspase 8 activity with the pharmacological inhibitor IETD prevents the loss of full-length CYLD and this correlates with the entry of the NEMO deficient cells into cell death by programmed necrosis."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...