IndraLab

Statements

CASP8 decreases the amount of CYLD. 4 / 8
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"Blockade of Caspase 8 activity with the pharmacological inhibitor IETD prevents the loss of full-length CYLD and this correlates with the entry of the NEMO deficient cells into cell death by programmed necrosis."
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"Levels of CYLD may be indirectly increased by allosteric inhibition of caspase 8 (which cleaves CYLD) by zVAD-FMK [XREF_BIBR]."
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"This decrease of caspase-8 levels in ELAVL1 KO cells did not result from a compromise of IFNγ signaling, as (i) KO expression of ELAVL1 decreased basal caspase-8 expression in the absence of IFNγ stimulation; and (ii) ELAVL1 KO did not block IFNγ-stimulated IRF1 and the downstream CYLD expression (Fig. 7 K and Fig. S5 B)."
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"As CYLD and caspase-8 are constitutively expressed in the tested human cancer cells and IFNγ stimulation further increases their expression (Fig. 2), we use shRNAs for CASP8 and CYLD to decrease the expression levels of caspase-8 and CYLD upon IFNγ stimulation to achieve a comparable level as that in untreated control cells (Fig. 3, C and E, lanes 4 versus lanes 1)."
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