IndraLab

Statements

MTORC2 increases the amount of KCNMA1. 4 / 4
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"By contrast, inhibition of mTORC2 downregulated BK channel protein expression and current density in podocytes."
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"The complex mTORC2, a novel regulator of BK channels in podocytes, not only regulates the distribution of BK channels through Akt, but also modulates BK channel protein expression through SGK1, in podocytes."
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"This is the first demonstration that mTORC2, but not mTORC1, could mediate BK channel protein expression and activity."
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"These results indicate mTORC2 not only regulates the distribution of BK channels through Akt, but also modulates BK channel protein expression via SGK1 in podocytes."
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