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BAP1 inhibits RAR. 6 / 6
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"Similar to ASXL1, BAP1 overexpression repressed RAR transcriptional activity ( Supplemental Fig. 2C )."
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"Co-expression of OGT led to a considerable increase in BAP1-mediated RAR repression ( Fig. 3 A), which was impaired following treatment with the OGT inhibitor alloxan ( Fig. 3 B)."
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"See also Figures equirement of BAP1 for ASXL1 mediated RAR repression."
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"BAP1 Is a Histone H2B Specific DUB In Vivo and In Vitro To gain insight into themechanisms of RAR repressionmediated by ASXL1 and BAP1, we first determined whether the deubiquiti- nase (DUB) activity [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Based on these data, we propose that BAP1 O -GlcNAcylation promotes RAR repression required for maintaining pluripotency, while its inhibition allows RAR activation to initiate ES cell differentiation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"(B) R ASXL1 for BAP1 mediated RAR repression."
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