IndraLab

Statements

USP9X inhibits MYC. 6 / 6
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"USP2215, USP2816 17, USP3718, and OTUD6A19 directly deubiquitinate c-Myc, increasing tumorigenesis, while USP9X indirectly reduces c-Myc by stabilizing its E3 ligase Fbw7, thereby inhibiting CRC growth20.HMGA2 is an architectural transcription factor composed of 109 amino acids and three AT-hooks, which are basic DNA-binding domains."
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"Hence, Usp9x controls tissue homeostasis in the murine gut by negatively regulating c-Myc and Notch1, most likely via stabilization of Fbw7."
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"Besides, USP9X negatively regulated c-Myc by directly stabilizing FBW7 to restore damaged intestinal epithelium and inhibit the development of colitis-associated colon cancer in animal models (140)."
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"In contrast, USP9x has been found to stabilize the E3 ubiquitin ligase Fbw7, inhibiting Myc as a tumor suppressor (13)."
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"In agreement with these findings, USP9X silencing using 2 different siRNAs increased c-MYC transcriptional activity in HCT116-FBW7 +/+ but not in HCT116-FBW7 Delta and Delta cells, as indicated by a dual luciferase c-MYC reporter assay (XREF_FIG)."
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"Thus, USP9X negatively regulates c-MYC activity via direct stabilization of FBW7."
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