IndraLab

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Silicon dioxide inhibits NLRP3. 5 / 5
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"Concentration of NLRP3, which is closely linked with oxidative stress and inflammation, was significantly elevated in the silica-instilled animals compared to controls (both p < 0.05 after 14 and 28 days, while treatment with EGCG lowered NLRP3 concentration after 14 days (p < 0.05) (Figure 1)."
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"Similar to the aberrant spatiotemporal expression of SOX2 and SOX9, the silica-induced NLRP3 inflammasome disrupted distribution of BASCs, which were ectopically expressed in the alveolar region on day 7 after silica exposure."
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"(2) Model of Lysosomal DisruptionCrystalline or particulate NLRP3 agonists such as MSU, silica and alum are engulfed, and their physical characteristics lead to lysosomal rupture, resulting in cytosolic release of lysosomal contents that are somehow sensed by the NLRP3 inflammasome."
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"In these studies, inhibiting actin polymerization via cytochalasin leads to the inhibition of silica induced activation of the NLRP3 inflammasome."
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"A , Enhanced IL-1beta release from ZD macrophages ( BMDM ) , which were primed with LPS ( 1 mug / ml , 4 h ) and then treated with increasing concentrations of the zinc chelation agent TPEN for 4 h. B , BMDMs were primed ( LPS 1 mug / ml , 4 h ) and treated with TPEN ( 10 mum ) with and without NLRP3 inhibition by MCC950 ( 10 mum ) ( Bi ) or silica ( 300 mug / ml ) with and without ZnCl2 ( 200 mum ) supplementation ( Bii ) ; the cells were lysed in the media and probed for ASC oligomerization , IL-1beta cleavage ( 17 kDa ) , ( casp 1 ) activation ( p10 ) , and gasdermin D cleavage ."
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