IndraLab

Statements

Silicon dioxide inhibits NLRP3. 2 / 2
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eidos
"A , Enhanced IL-1beta release from ZD macrophages ( BMDM ) , which were primed with LPS ( 1 mug / ml , 4 h ) and then treated with increasing concentrations of the zinc chelation agent TPEN for 4 h. B , BMDMs were primed ( LPS 1 mug / ml , 4 h ) and treated with TPEN ( 10 mum ) with and without NLRP3 inhibition by MCC950 ( 10 mum ) ( Bi ) or silica ( 300 mug / ml ) with and without ZnCl2 ( 200 mum ) supplementation ( Bii ) ; the cells were lysed in the media and probed for ASC oligomerization , IL-1beta cleavage ( 17 kDa ) , ( casp 1 ) activation ( p10 ) , and gasdermin D cleavage ."
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reach
"In these studies, inhibiting actin polymerization via cytochalasin leads to the inhibition of silica induced activation of the NLRP3 inflammasome."
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