IndraLab

Statements

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"These results indicate that CCND1 and USP28 are upregulated in A549 cells, and knockdown of CCND1 or USP28 obviously restrains cell proliferation and promotes apoptosis."
27988424
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"Further, we found that USP28 promoted PC cell growth by facilitating cell cycle progression and inhibiting apoptosis."
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"Moreover, cell apoptosis is triggered by a reduction in USP28 [192]."
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"However, some studies have indicated that USP28 deficiency leads to apoptosis [42]."
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"miR-3940-5p can target CCND1 and USP28 to inhibit the growth of NSCLC cells, and overexpression of CCND1 and USP28 can attenuate miR-3940-5P-induced proliferation and apoptosis of NSCLC cells (88)."
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"The specific mechanism by which USP28 deficiency induces apoptosis is still unclear."
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"Loss of USP28, renders cells resistant to IR-induced apoptosis, similar to what has been seen with Chk2, p53 and PUMA null mice."
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"XREF_BIBR reported that overexpression of USP28 promotes NSCLC cell proliferation and apoptosis inhibition and is associated with poor prognosis in NSCLC patients."
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