IndraLab

Statements

Pyraclofos activates KCNK2. 4 / 4
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"Strikingly, replacement of intracellular K + by Rb + increased the voltage dependent activation of TREK-1 around 100-fold, resulting in large outward currents and large tail currents (XREF_FIG A)."
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"Two electrode voltage clamp studies showed that ML67 activated the closest K 2.1 (TREK-1) homologue (Supplementary Figure S4) K 10.1 (TREK-2) (EC ∼250 μM) but not the more distantly related K 3.1 (TASK-1) (Figure 2F)."
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"TREK-1 currents were elicited by a 10 mV voltage step protocol from −100 mV to +100 mV, from a −80 mV holding potential."
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"Furthermore, activation by PIP 2, intracellular pH and membrane stretch have been shown to abolish voltage activation in TREK-1, thus effectively causing a gating mode shift."
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