IndraLab

Statements

USP7 activates AKT. 6 / 6
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"[15] USP7 also mediates regulation of the Akt antagonist PTEN and affects its localization."
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"Ubiquitination‐based Co‐IP showed that USP7 had the ability to decrease the total poly‐ubiquitination level of AKT (Figure 5N,O), further proving that USP7 inhibited AKT proteasome degradation via deubiquitinated AKT."
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"USP7 also may increase the metastatic potential of AKT by deubiquitinating its target HIF-1α [91]."
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"Moreover, USP7 siRNA blocked the activation of Akt/ERK signaling pathway."
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"SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation."
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"In OSCC cells, USP7 was shown to promote cell proliferation, inhibit apoptosis, enhance cell migration and invasion, and activate the Akt/ERK pathway."
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