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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

U18666A activates SCN2A. 2 / 2

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"The same results were obtained when ScN2a cells were treated with U18666A, which is frequently used to induce a Niemann-Pick type C disease phenotype in cultured cells, characterized by accumulation of cholesterol in late endosomes and lysosomes [XREF_BIBR]."

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"In ScN2a cells treated with U18666A, we observed that rab 9 overexpression partially rescued PrP Sc propagation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...