IndraLab

Statements

USP18 inhibits Neoplasms. 11 / 11
| 11
reach
"Tumor volume and weight were decreased in sh-USP18 group or sh-POU4F1 group of xenograft mice relative to sh-NC group, while overexpression of POU4F1 or PRKAA2 respectively rescued the tumor growth inhibition caused by sh-USP18 or sh-POU4F1 (Fig. 7B-C)."
40122823
reach
"Since the NLRP3 inflammasome can be formed and activated by DAMPs, PLK2-induced DAMPs release could also be important for GSDMD pathway activation in USP18 depleted tumor environment in vivo."
36646704
reach
"Finally, to further test for ICD in Usp18-depleted tumors, we used the gold standard vaccination assay (Supplementary Fig. 10a)."
36646704
reach
"Since the NLRP3 inflammasome can be formed and activated by DAMPs, PLK2-induced DAMP release could also be crucial for GSDMD pathway activation in the USP18-depleted tumor environment in vivo."
38799433
reach
"These results suggest that USP18 deletion leads to CSF1R downregulation in TAMs and a decrease in pro-tumor/immunosuppressive macrophages, contributing to enhanced anti-tumor macrophage polarization, consequently promoting a Th1-dominant TME and enhancing CD8 T cell-mediated anti-tumor immunity, in agreement with previous reports."
38100351
reach
"However, according to research by Hong et al., increased USP18 expression in tumor cells would in turn inhibit carcinogenesis, whereas decreased USP18 promotes tumor growth and lowers immunosurveillance by decreasing the exogenous synthesis of IFN-γ and the survival of cytotoxic T lymphocytes (CTLs) in TME [178]."
37658402
reach
"In the breast cancer spontaneous PyVmT mouse model of mammary tumorigenesis, initial evidence showed that Usp18 knock-out mice had reduced tumor growth and increased CD4 + T cell infiltrates as flow c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31481283
reach
"mRNA and protein levels of USP18 are found to be elevated in diverse cancers and USP18 loss has been shown to restrict tumor growth."
38645224
reach
"USP18 loss in murine CT26 tumors inhibits tumor growth in vivo."
38632987
reach
"To determine if USP18 loss can inhibit in vivo tumor growth in the presence of physiological Type I IFN concentrations, we genetically ablated murine Usp18 (mUsp18) in murine CT26 colorectal cancer cells (mUsp18 CT26)."
38632987
reach
"IFN-γ signaling induces USP18 expression in B16 melanoma tumor cells, thus suppressing tumor growth in vivo."
31078284