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ATP activates KCNQ1. 5 / 6
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"Furthermore, PIP 2 sensitivity of I Ks is modulated by the KCNE1 subunit, whereas ATP activation of KCNQ1 channels is independent of simultaneous expression of KCNE1 [23]."
25892084
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"Here we show that intracellular ATP activates heterologously coexpressed KCNQ1 and KCNE1 as well as I (Ks) in cardiac myocytes by directly binding to the C terminus of KCNQ1 to allow the pore to open."
24190995
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"Li et al. [XREF_BIBR] found that elevated intracellular ATP enhances the KCNQ1 and KCNE1 activation in Xenopus oocytes and shortens the APD in cardiomyocytes."
33322401
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"Using simultaneous patch-clamp and FRET measurement, Kienitz and Vladimirova [XREF_BIBR] found that a loss of ATP slowed the activation of KCNQ1 and KCNE1 in Chinese hamster ovary (CHO) cells."
33322401
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"As we will consider further, modulation of KCNE1 and KCNQ1 channel complexes by ATP and Ca ++ may constitute a protective mechanism against NIHL."
18790034