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USP2 activates TGFB. 2 / 2

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"We have previously reported that USP2 positively regulates TGF-β signaling in tumor parenchymal cells by promoting deubiquitylation of TGFBR1 and participates in tumor genesis and metastasis (Zhao et al., 2018)."

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"To examine whether USP2 directly regulates TGF-β signaling in vitro, we isolated RFP LPMCs from Lyz2-Cre;Usp2 Ai14 and Lyz2-Cre;Ai14 mice and stimulated them with TGF-β for 30 min or 4 h followed by flow cytometry with p-SMAD2 and Ki67."

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USP2 activates TGFB. 2 / 2

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