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USP8 activates CDH2. 2 / 2
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"So, USP8 has been proved to have a positive correlation with Cx43 leading to inhibit E-cadherin and thus activate N-cadherin causing breast cancer cell proliferation and metastasis which targeting USP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here in this study, we found that knocking down USP8 significantly inhibited the PCa cell migration by suppressing the EMT process through the increased E-cadherin and decreased N-cadherin, whereas USP8 overexpression promoted the EMT process through the decreased E-cadherin and increased N-cadherin and so thereby increased the migration of both DU145 and PC3 cells.Knocking down USP8 downregulated the NF-κB signal by decreasing its intermediatory proteins (IKK, P-IKB, p65, and P-p65), whereas USP8 overexpression promoted the NF-κB signal by increasing its intermediatory proteins."
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