IndraLab

Statements

USP7 activates proteolysis. 5 / 5
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"Therefore, we reasoned that ablation of HAUSP may drive N-Myc proteolysis."
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"As Usp7 is a deubiquitinase and prevents protein degradation, Uhrf1 protein abundance decreased in T cells after treatment with the Usp7 inhibitor (XREF_FIG)."
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"USP7 as a deubiquitinase sustained PLK1 protein stability via the C223 site, and inversely, USP7 inhibition by P5091 promoted the protein degradation of PLK1 through the ubiquitination-proteasome pathway."
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"It has also been shown that the inhibition USP7 and USP2a which are de-ubiquitinases of Hdm2, increases Hdm2 proteolysis and stabilizes p53 levels in multiple myeloma cells enabling the initiation of apoptosis."
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"USP7 counteracts SCFbetaTrCP- but not APCCdh1 mediated proteolysis of Claspin."
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