IndraLab

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Galangin inhibits NLRP3. 3 / 3
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"Moreover, western blotting showed that galangin treatment effectively inhibited nuclear factor-kappa B (NF-kappaB), phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) and nucleotide-binding domain- (NOD-) like receptor protein 3 (NLRP3) signaling pathway activation."
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"To better understand the synergistic antitumor effect of galangin in combination with 5-FU and its related molecular mechanism in esophageal cancer, we sought to determine whether galangin can further inactivate the NLRP3 pathway to suppress inflammation and inhibit tumorigenicity in addition to standard therapy."
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"Increased chemotherapy sensitivity, which was reflected by apoptosis activation, was further identified when NLRP3 was suppressed by galangin after an initial 5-FU treatment."
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