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USP8 leads to the deubiquitination of TRAF6. 5 / 5
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"USP8 induces the deubiquitination of TRAF6-associated proteins for the activation of NF-kappaB."
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"Therefore, we examined whether USP8 induces the deubiquitination of TRAF6."
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"The ubiquitination of TRAF6 could be seen in the absence of Myc-USP8 (Fig. 1E, lane 2), whereas the marked deubiquitination of TRAF6 was observed in the presence of Myc-USP8 in a dose-dependent manner (Fig. 1E, lane 3–5), indicating that USP8 induces the deubiquitination of TRAF6, as depicted in Fig. 1F."
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"Having shown that USP8 induces the deubiquitination of TRAF6, TAB2, and TAK1, and resulted in the attenuation of NF-κB activation induced by TLR4 stimulation, we further investigated whether USP8 induces the deubiquitination of BECN1 and p62."
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"Based on the findings that USP8 induced the deubiquitination of TRAF6-associated proteins, such as TRAF6, TAK1 (MAP3K7), TAB2, BECN1, and p62 (SQSTM1), for the activation of NF-κB and autophagy in response to TLR4, the GEPIA database was used to analyze the correlation between USP8 and these genes in the normal and LIHC cells."
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