IndraLab

Statements

sparser
"The formation of β1-integrin–Kv1.3 channel supramolecular proximity complexes may be particularly important in view of the reduced in vitro invasiveness and the small, but significant reduction in in vivo metastasis found using verapamil ( xref ; xref ; xref ; xref )."
12084773
sparser
"In melanoma cells, the interaction of Kv1.3 with β1-integrin (confirmed here both by BioID and Myc-Trap coimmunoprecipitation) was shown to be modulated by Kv1.3 inhibitors, suggesting that Kv1.3 blockers might have an impact on cancer cell behavior by affecting the assembly of supramolecular structures containing integrins and possibly other proteins ( xref ), although this hypothesis has not been experimentally tested."
39231216
sparser
"Although verapamil per se is not likely to be broadly used in managing disease, the identification of a molecular pathway contributing to its action, such as the control of β1-integrin-to-Kv1.3 channel interactions, may lead to more effective therapeutic approaches."
12084773